Aoshuang Chen PhD » MBT Faculty and Staff

Aoshuang Chen PhD » MBT Faculty and Staff 2017-08-01T10:19:56+00:00

Aoshuang Chen PhD

Associate Professor University of Illinois College of Medicine RockfordBiomedical Science
Work 1601 Parkview Avenue Rockford IL 61107 Work Phone: 815-395-5692Work Fax: 815-395-5666 Website: Publications in PubMed Website: Biosketch
Photo of Aoshuang Chen PhD

Biographical Info

Modifying T-cell Responses to Ameliorate Immune Diseases
Immunization against autoimmune diseases

To induce tolerance to antigens via immunization, we previously developed the “suppressed immunization” (“SI”) method. In this method, the glucocorticoid immunosuppressant dexamethasone is used as a “tolerogenic adjuvant” during antigen immunization. We showed that SI can preferentially expand antigen-specific CD4+Foxp3+ regulatory T (Treg) and IL-10+ B-1 B cells concomitantly, while blocking the recall responses of effector T (Teff) and B-2 B cells. In Balb/c mice with pre-established delayed-type hypersensitivity (DTH) to hen ovalbumin (OVA), we showed that SI with an OVA-derived peptide causes long-term desensitization to OVA rechallenge. In the NOD mouse model of type 1 diabetes, we showed that SI with an insulin-derived peptide blocks the progression of spontaneous diabetes. Our current research goals are:

To determine the molecular and cellular mechanisms underlying the tolerogenic efficacy of SI.
To explore the protective efficacy of SI in other autoimmune and inflammatory disease models, including the ApoE-/- mouse model of atherosclerosis and diet-induced obesity (DIO) mouse model of type 2 diabetes.
To identify new auto-antigens contributing to the inflammatory process of these diseases and explore them as targets in SI.

Selected Publications:
Chen, A., Liu, S., Park, D., Kang, Y., & Zheng, G. (2007). Depleting intratumoral CD4+CD25+ regulatory T cells via FasL protein transfer enhances the therapeutic efficacy of adoptive T cell transfer. Cancer Research, 67(3), 1291-1298. doi:67/3/1291 [pii]

Chen, A., Xu, H., Choi, Y., Wang, B., & Zheng, G. (2004). TRANCE counteracts FasL-mediated apoptosis of murine bone marrow-derived dendritic cells. Cellular Immunology, 231(1-2), 40-48. doi:S0008-8749(04)00183-2 [pii]

Liu, S., Foster, B. A., Chen, T., Zheng, G., & Chen, A. (2007). Modifying dendritic cells via protein transfer for antitumor therapeutics. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 13(1), 283-291. doi:13/1/283 [pii]

Zheng, G., Liu, S., Wang, P., Xu, Y., & Chen, A. (2006). Arming tumor-reactive T cells with costimulator B7-1 enhances therapeutic efficacy of the T cells. Cancer Research, 66(13), 6793-6799. doi:66/13/6793 [pii]

Zheng, G., Wang, B., & Chen, A. (2004). The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. Journal of Immunology (Baltimore, Md.: 1950), 173(4), 2428-2434. doi:173/4/2428 [pii]

Categories: Biomedical Science
Updated 2 months ago.

Department of Biomedical Science Staff

Biomedical Department Scientists

Aoshuang Chen, PhD, Associate Professor, aoshuang@uic.edu

Ramaswamy Kalyanasundaram, DVM, PhD, Professor, ramswamy@uic.edu

Xue-Jun (June) Li, PhD, Associate Professor, xjli23@uic.edu

Mathew Mathew, PhD, Associate Professor, mtmathew@uic.edu

Gnanasekar Munirathiam, Associate Professor, mgnanas@uic.edu

Karin Nitiss, Research Associate Professor, knitiss@uic.edu

Neelu Puri, Associate Professor, neelupur@uic.edu

Guoxing Zheng, Associate Professor, guoxingz@uic.edu

 

Department of Biomedical Sciences Administrative Staff

Department Head

Ramaswamy Kalyanasundaram, DVM, PhD ramaswamy@uic.edu
Professor and Head, Department of Biomedical Sciences

 

Biomedical Sciences Administration

Nancy Olson, Business Manager
nanolson@uic.edu

Janet Stull Snow, Program Administrative Assistant
jlss@uic.edu

 

Research Support

Andrew Canciamille, acanci2@uic.edu

Jessica Gorman, jgorma2@uic.edu

Joseph Orthoefer, DVM, josepho@uic.edu

Laura Sykaluk, Research Technologist, lsykal2@uic.edu

 

Master in Medical Biotechnology Program Administration

Khalifah Sidik, PhD, Director, khsidik@uic.edu

Sarah Hays, Assistant Director, sarhays@uic.edu

Wendy Schultz, site-specific Registrar functions, wschultz@uic.edu

 

Adjunct Faculty

Deborah Breiter, PhD, Adjunct Instructor

Specialty:  Immunology, Cell Biology, Biochemistry

Rockford University

 

Ryan Bomgarden, PhD, Adjunct Instructor

Specialty:  Molecular Biology, Cell Biology

Thermo Fisher Scientific

 

E. Thomas Carey, PharmD, Adjunct Instructor

Specialty:  Pharmacology

SwedishAmerican – A Division of UW Health

 

Isaac Cha, PharmD, Clinical Assistant Professor

Specialty:  Pharmacology

University of Illinois College of Medicine at Chicago

University of Illinois College of Pharmacy at Rockford

 

Jae Choi, PhD, Adjunct Assistant Professor

Specialty:  Research & Development

Thermo Fisher Scientific

 

Surbhi Desai, PhD, Adjunct Instructor

Specialty:  Immunology, Proteomics

Thermo Fisher Scientific

 

Joshua Edwards, PhD, Adjunct Instructor

Specialty:  Pharmacology

Midwestern University

 

Megan Fleischmann, PharmD

Specialty:  Pharmacology

University of Illinois College of Medicine at Rockford, Family Health Center

 

Lawrence D. Frenkel, MD, Adjunct Professor

Specialty:  Microbiology

Georgetown University School of Medicine

 

Keith Glaser, PhD, Adjunct Professor

Specialty:  Drug Development

Abbott Laboratories

 

Wade Green, PhD, Adjunct Instructor

Specialty:  Entrepreneur Start-up, Intellectual Property

Office of Technology Management, University of Illinois at Chicago

 

Leslyn Hanakahi, PhD, Adjunct Assistant Professor

Specialty:  Molecular Biophysics, Biochemistry

Department of Pharmacy, University of Illinois at Chicago

 

Paul Haney, PhD, Adjunct Instructor

Specialty:  Cell Biology, Biochemistry

Thermo Fisher Scientific

 

Rita Highland, RN, Adjunct Instructor

Specialty:  Clinical Lab Instruction

SwedishAmerican – A Division of UW Health

 

Scott Homann, MD, Associate Professor

Specialty:  Infectious Disease

University of Illinois College of Medicine at Rockford

Rockford Infectious Disease

 

Rohit Kolhatkar, PhD, Adjunct Assistant Professor

Specialty:  Drug Delivery, Nanotechnology

Department of Pharmacy, University of Illinois at Chicago

 

N. Martin MacDowell, Jr., Research Associate Professor

Specialty:  National Center for Rural Health Professionals

University of Illinois College of Medicine at Rockford, Department of Family and Community Medicine

 

John Nitiss, PhD, Adjunct Professor

Specialty:  Anticancer, Therapeutics and Imaging

University of Illinois College of Pharmacy at Rockford

 

Marie Nlend, PhD, Adjunct Instructor

Specialty:  Immunohistochemistry

Thermo Fisher Scientific

 

Richard Olson, MD, Adjunct Instructor

Specialty:  Clinical Research

Rockford Orthopedic Associates

 

Ray Ortiz, HT (ASCP), QIHC

Specialty:  Immunohistochemistry

MercyRockford Health System

 

Jacob Peuler, PhD, Adjunct Professor

Specialty:  Pharmacology

Midwestern University

 

Walter Prozialeck, PhD, Adjunct Research Professor

Specialty:  Pharmacology

Midwestern University

 

Kianoush Sheykholeslami, MD, PhD, Adjunct Assistant Professor

Specialty: Neuroscience, Head/Neck Surgery

MercyRockford Health System

 

Troy Skwor, PhD., Adjunct Instructor

Specialty:  Chemical/Biological Research

Rockford University

 

Thomas Smith, PhD, Adjunct Instructor

Specialty:  Biostatistics

Northern Illinois University

 

James Stim, MD, Adjunct Assistant Professor

Specialty:  Pharmacology

Rockford Nephrology Associates

 

James Sturm, MD, Adjunct Instructor

Specialty:  Anesthesiology, Pharmacology

MercyRockford Health System

 

Lindsey Tompkins, MS

Specialty:  IRB Statistics

Rockford Cardiovascular Associates

 

Geoffrey Tsaras, MD, Adjunct Clinical Instructor

Specialty:  Infectious Disease

Rockford Infectious Disease

 

Michael Tyrkus, PhD, Adjunct Instructor

Specialty:  Cytogenetics

MercyRockford Heath System

 

Krishna Vattem, PhD, Adjunct Instructor

Specialty:  Molecular Biology

Thermo Fisher Scientific

 

Kapila Viges, PhD, Adjunct Instructor

Specialty:  Entrepreneur Start-up

EnterpriseWorks, University of Illinois at Chicago

 

Brian Webb, PhD, Adjunct Professor

Specialty:  Molecular Biology

Thermo Fisher Scientific