Guoxing Zheng PhD » MBT Faculty and Staff

Guoxing Zheng PhD » MBT Faculty and Staff 2017-08-01T10:19:56+00:00

Guoxing Zheng PhD

Associate Professor University of Illinois College of Medicine RockfordBiomedical Science
Work 1601 Parkview Avenue Rockford IL 61107 Work Phone: 815-395-5691Work Fax: 815-395-5666 Website: Publications in PubMed Website: Dr. Guozing Zheng's CV/biosketch
Photo of Guoxing Zheng PhD

Biographical Info

Mechanisms of adaptive immune tolerance

We are interested in understanding the cellular and molecular mechanisms involved in either breaking or inducing T cell non-responsiveness to specific antigens. Using a method of protein transfer we are able to add lipid-derivatized immune-stimulating proteins, including T cell costimulators and cytokines, directly onto the surfaces of T cells, dendritic cells, and tumor cells ex vivo and in situ. This creates novel, and enhanced, interactions between these cell types and may ultimately allow the breaking of tumor tolerance. This line of work has led to the design of novel cellular cancer vaccines and therapeutic T cells for both active and passive cancer immunotherapies, respectively. We are also interested in defining the conditions of antigen presentation that potentiate adaptive T cell tolerance. This line of research has led to the finding that antigen immunization under glucocorticoid-induced immunosuppression can attenuate established memory responses by T and B cells. In particular, the glucocorticoid dexamethasone can function as a tolerogenic adjuvant by preferentially inducing apoptosis of dendritic cells (cDCs and pDCs), effector CD4+ T cells, and B-2 cells; whereas CD11cloCD40loCD86hiMHCIIlo macrophages, CD4+Foxp3+ Treg cells, and IL-10+ B-1 cells are relatively protected. As a result, Ag immunization in the presence of Dex raises Ag-specific Treg and B-1 cells while blocking the recall responses of Teff and B-2 cells, which leads to adaptive tolerance. The Treg cells represent the principal tolerizing effectors raised by SI, whereas the role the B-1 cells is currently being investigated. A hypothesis we are currently testing, in collaboration with Dr. Aoshuang Chen, is whether vaccines for common inflammatory or autoimmune diseases, such as atherosclerosis, type 1 diabetes, and type 2 diabetes may be designed to consist of dexamethasone and a disease-specific antigen(s).

Selected Publications:

Cutting edge: Dexamethasone potentiates the responses of both regulatory T cells and B-1 cells to antigen immunization in the ApoE(-/-) mouse model of atherosclerosis. Chen A, Geng Y, Ke H, Constant L, Yan Z, Pan Y, Lee P, Tan I, Williams K, George S, Munirathinam G, Reardon CA, Getz GS, Wang B, Zheng G. J Immunol. 2014 Jul 1;193(1):35-9. doi: 10.4049/jimmunol.1302469. Epub 2014 Jun 4. PMID: 24899497

Palmitate-derivatized human IL-2: a potential anticancer immunotherapeutic of low systemic toxicity. Chou SH, Shetty AV, Geng Y, Xu L, Munirathinam G, Pipathsouk A, Tan I, Morris T, Wang B, Chen A, Zheng G. Cancer Immunol Immunother. 2013 Mar;62(3):597-603. doi: 10.1007/s00262-012-1364-8. Epub 2012 Nov 4. PMID: 23124508

Dexamethasone promotes tolerance in vivo by enriching CD11clo CD40lo tolerogenic macrophages. Zheng G, Zhong S, Geng Y, Munirathinam G, Cha I, Reardon C, Getz GS, van Rooijen N, Kang Y, Wang B, Chen A. Eur J Immunol. 2013 Jan;43(1):219-27. doi: 10.1002/eji.201242468. Epub 2012 Nov 7. PMID: 23001956

Cutting edge: Immunosuppressant as adjuvant for tolerogenic immunization.

Kang Y, Xu L, Wang B, Chen A, Zheng G. J Immunol. 2008 Apr 15;180(8):5172-6. PMID:18390698

Categories: Biomedical Science
Updated 4 months ago.

Department of Biomedical Science Staff

Biomedical Department Scientists

Aoshuang Chen, PhD, Associate Professor, aoshuang@uic.edu

Ramaswamy Kalyanasundaram, DVM, PhD, Professor, ramswamy@uic.edu

Xue-Jun (June) Li, PhD, Associate Professor, xjli23@uic.edu

Mathew Mathew, PhD, Associate Professor, mtmathew@uic.edu

Gnanasekar Munirathiam, Associate Professor, mgnanas@uic.edu

Karin Nitiss, Research Associate Professor, knitiss@uic.edu

Neelu Puri, Associate Professor, neelupur@uic.edu

Guoxing Zheng, Associate Professor, guoxingz@uic.edu

 

Department of Biomedical Sciences Administrative Staff

Department Head

Ramaswamy Kalyanasundaram, DVM, PhD ramaswamy@uic.edu
Professor and Head, Department of Biomedical Sciences

 

Biomedical Sciences Administration

Nancy Olson, Business Manager
nanolson@uic.edu

Janet Stull Snow, Program Administrative Assistant
jlss@uic.edu

 

Research Support

Andrew Canciamille, acanci2@uic.edu

Jessica Gorman, jgorma2@uic.edu

Joseph Orthoefer, DVM, josepho@uic.edu

Laura Sykaluk, Research Technologist, lsykal2@uic.edu

 

Master in Medical Biotechnology Program Administration

Khalifah Sidik, PhD, Director, khsidik@uic.edu

Sarah Hays, Assistant Director, sarhays@uic.edu

Wendy Schultz, site-specific Registrar functions, wschultz@uic.edu

 

Adjunct Faculty

Deborah Breiter, PhD, Adjunct Instructor

Specialty:  Immunology, Cell Biology, Biochemistry

Rockford University

 

Ryan Bomgarden, PhD, Adjunct Instructor

Specialty:  Molecular Biology, Cell Biology

Thermo Fisher Scientific

 

E. Thomas Carey, PharmD, Adjunct Instructor

Specialty:  Pharmacology

SwedishAmerican – A Division of UW Health

 

Isaac Cha, PharmD, Clinical Assistant Professor

Specialty:  Pharmacology

University of Illinois College of Medicine at Chicago

University of Illinois College of Pharmacy at Rockford

 

Jae Choi, PhD, Adjunct Assistant Professor

Specialty:  Research & Development

Thermo Fisher Scientific

 

Surbhi Desai, PhD, Adjunct Instructor

Specialty:  Immunology, Proteomics

Thermo Fisher Scientific

 

Joshua Edwards, PhD, Adjunct Instructor

Specialty:  Pharmacology

Midwestern University

 

Megan Fleischmann, PharmD

Specialty:  Pharmacology

University of Illinois College of Medicine at Rockford, Family Health Center

 

Lawrence D. Frenkel, MD, Adjunct Professor

Specialty:  Microbiology

Georgetown University School of Medicine

 

Keith Glaser, PhD, Adjunct Professor

Specialty:  Drug Development

Abbott Laboratories

 

Wade Green, PhD, Adjunct Instructor

Specialty:  Entrepreneur Start-up, Intellectual Property

Office of Technology Management, University of Illinois at Chicago

 

Leslyn Hanakahi, PhD, Adjunct Assistant Professor

Specialty:  Molecular Biophysics, Biochemistry

Department of Pharmacy, University of Illinois at Chicago

 

Paul Haney, PhD, Adjunct Instructor

Specialty:  Cell Biology, Biochemistry

Thermo Fisher Scientific

 

Rita Highland, RN, Adjunct Instructor

Specialty:  Clinical Lab Instruction

SwedishAmerican – A Division of UW Health

 

Scott Homann, MD, Associate Professor

Specialty:  Infectious Disease

University of Illinois College of Medicine at Rockford

Rockford Infectious Disease

 

Rohit Kolhatkar, PhD, Adjunct Assistant Professor

Specialty:  Drug Delivery, Nanotechnology

Department of Pharmacy, University of Illinois at Chicago

 

N. Martin MacDowell, Jr., Research Associate Professor

Specialty:  National Center for Rural Health Professionals

University of Illinois College of Medicine at Rockford, Department of Family and Community Medicine

 

John Nitiss, PhD, Adjunct Professor

Specialty:  Anticancer, Therapeutics and Imaging

University of Illinois College of Pharmacy at Rockford

 

Marie Nlend, PhD, Adjunct Instructor

Specialty:  Immunohistochemistry

Thermo Fisher Scientific

 

Richard Olson, MD, Adjunct Instructor

Specialty:  Clinical Research

Rockford Orthopedic Associates

 

Ray Ortiz, HT (ASCP), QIHC

Specialty:  Immunohistochemistry

MercyRockford Health System

 

Jacob Peuler, PhD, Adjunct Professor

Specialty:  Pharmacology

Midwestern University

 

Walter Prozialeck, PhD, Adjunct Research Professor

Specialty:  Pharmacology

Midwestern University

 

Kianoush Sheykholeslami, MD, PhD, Adjunct Assistant Professor

Specialty: Neuroscience, Head/Neck Surgery

MercyRockford Health System

 

Troy Skwor, PhD., Adjunct Instructor

Specialty:  Chemical/Biological Research

Rockford University

 

Thomas Smith, PhD, Adjunct Instructor

Specialty:  Biostatistics

Northern Illinois University

 

James Stim, MD, Adjunct Assistant Professor

Specialty:  Pharmacology

Rockford Nephrology Associates

 

James Sturm, MD, Adjunct Instructor

Specialty:  Anesthesiology, Pharmacology

MercyRockford Health System

 

Lindsey Tompkins, MS

Specialty:  IRB Statistics

Rockford Cardiovascular Associates

 

Geoffrey Tsaras, MD, Adjunct Clinical Instructor

Specialty:  Infectious Disease

Rockford Infectious Disease

 

Michael Tyrkus, PhD, Adjunct Instructor

Specialty:  Cytogenetics

MercyRockford Heath System

 

Krishna Vattem, PhD, Adjunct Instructor

Specialty:  Molecular Biology

Thermo Fisher Scientific

 

Kapila Viges, PhD, Adjunct Instructor

Specialty:  Entrepreneur Start-up

EnterpriseWorks, University of Illinois at Chicago

 

Brian Webb, PhD, Adjunct Professor

Specialty:  Molecular Biology

Thermo Fisher Scientific