Neelu Puri PhD » MBT Faculty and Staff

Neelu Puri PhD » MBT Faculty and Staff 2017-08-25T11:53:52+00:00

Neelu Puri PhD

Assistant Professor University of Illinois College of Medicine RockfordBiomedical Science
Work 1601 Parkview Avenue Rockford IL 61107 Work Phone: 815-395-5678Work Fax: 815-395-5666 Website: Publications in PubMed Website: Dr. Puri’s CV/biosketch
Photo of Neelu Puri PhD

Biographical Info

Cancer therapy and Obesity research

Dr. Puri’s research focuses on two major areas:

1) Cancer therapy:

T-oligo: Her cancer therapy research focuses on developing novel targeted therapies using T-oligo. She and her team have found T-oligo (nucleotides homologous to the telomere overhang) to be therapeutically effective in lung cancer and melanoma cells and pre-established tumor xenografts by inducing apoptosis and senescence. She is currently attempting to deliver T-oligo as a nanoparticle complexed with a cationic peptide to melanoma tumors in mice.

Lung Cancer: Her project on lung cancer aims to unravel the mechanism of EGFR/c-Met tyrosine kinase inhibitor (TKI) resistance in Non-Small Cell lung cancer by studying the signaling pathways in resistant and parental NSCLC cell lines with and without EGFR TK mutations. Recent studies in her lab demonstrate activation of alternative signaling pathways in resistant cell lines which can be targeted along with EGFR and c-Met pathways to overcome or delay the TKI resistance. Currently, she is also investigating the role of epithelial mesenchymal transition in the development of resistance in NSCLC. Her translational research focuses on identifying the role of biomarkers EGFR/c-Met and key proteins from the mTOR and Wnt signaling pathways, in prognosis of NSCLC patients using immunohistochemistry.

Melanoma: Her cancer research also focuses on melanoma, where she has successfully evaluated the role of c-Met as a molecular target in melanoma. She is currently investigating the mechanism and TKI combination therapies to overcome c-Met and BRAF resistance in wild type and melanoma cell lines with a BRAF mutation.

2) Role of FTO in obesity:

This project aims at identifying the role of FTO in promoting obesity in humans. She has downregulated FTO with siRNA and using a microarray studied affected genes. Dr. Puri has constructed a pathway from the microarray data and is currently identifying key targets. She is investigating the mechanism of how FTO induces obesity. Her recent studies indicate that FTO modulates intracellular energy levels and downstream signaling mechanisms which control energy intake and metabolism.

Selected Publications:
Fong, J. T., Jacobs, R. J., Moravec, D. N., Uppada, S. B., Botting, G. M., Nlend, M., Puri, N. (2013). Alternative signaling pathways as potential therapeutic targets for overcoming EGFR and c-met inhibitor resistance in non-small cell lung cancer. PloS One, 8(11), e78398. doi:10.1371/journal.pone.0078398 [doi]

Mulnix, R. E., Pitman, R. T., Retzer, A., Bertram, C., Arasi, K., Crees, Z., Girard, J., Uppada, S. B., Stone, A. L., Puri, N. (2013). hnRNP C1/C2 and pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang. OncoTargets and Therapy, 7, 23-32. doi:10.2147/OTT.S54575 [doi]

Pitman, R. T., Fong, J. T., Billman, P., & Puri, N. (2012). Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner. PloS One, 7(6), e38444. doi:10.1371/journal.pone.0038444 [doi]

Pitman, R. T., Wojdyla, L., & Puri, N. (2013). Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma. Oncotarget, 4(5), 761-771. doi:1047 [pii]

Puri, N., Pitman, R. T., Mulnix, R. E., Erickson, T., Iness, A. N., Vitali, C., et al. (2014). Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides. Cancer Letters, 343(1), 14-23. doi:10.1016/j.canlet.2013.09.010 [doi]

Uppada, S. B., Erickson, T., Wojdyla, L., Moravec, D. N., Song, Z., Cheng, J., Puri, N. (2014). Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy. International Journal of Nanomedicine, 9, 43-53. doi:10.2147/IJN.S55133 [doi]

Categories: Biomedical Science
Updated 4 weeks ago.

Department of Biomedical Science Staff

Biomedical Department Scientists

Aoshuang Chen, PhD, Associate Professor, aoshuang@uic.edu

Ramaswamy Kalyanasundaram, DVM, PhD, Professor, ramswamy@uic.edu

Xue-Jun (June) Li, PhD, Associate Professor, xjli23@uic.edu

Mathew Mathew, PhD, Associate Professor, mtmathew@uic.edu

Gnanasekar Munirathiam, Associate Professor, mgnanas@uic.edu

Karin Nitiss, Research Associate Professor, knitiss@uic.edu

Neelu Puri, Associate Professor, neelupur@uic.edu

Guoxing Zheng, Associate Professor, guoxingz@uic.edu

 

Department of Biomedical Sciences Administrative Staff

Department Head

Ramaswamy Kalyanasundaram, DVM, PhD ramaswamy@uic.edu
Professor and Head, Department of Biomedical Sciences

 

Biomedical Sciences Administration

Nancy Olson, Business Manager
nanolson@uic.edu

Janet Stull Snow, Program Administrative Assistant
jlss@uic.edu

 

Research Support

Andrew Canciamille, acanci2@uic.edu

Jessica Gorman, jgorma2@uic.edu

Joseph Orthoefer, DVM, josepho@uic.edu

Laura Sykaluk, Research Technologist, lsykal2@uic.edu

 

Master in Medical Biotechnology Program Administration

Khalifah Sidik, PhD, Director, khsidik@uic.edu

Sarah Hays, Assistant Director, sarhays@uic.edu

Wendy Schultz, site-specific Registrar functions, wschultz@uic.edu

 

Adjunct Faculty

Deborah Breiter, PhD, Adjunct Instructor

Specialty:  Immunology, Cell Biology, Biochemistry

Rockford University

 

Ryan Bomgarden, PhD, Adjunct Instructor

Specialty:  Molecular Biology, Cell Biology

Thermo Fisher Scientific

 

E. Thomas Carey, PharmD, Adjunct Instructor

Specialty:  Pharmacology

SwedishAmerican – A Division of UW Health

 

Isaac Cha, PharmD, Clinical Assistant Professor

Specialty:  Pharmacology

University of Illinois College of Medicine at Chicago

University of Illinois College of Pharmacy at Rockford

 

Jae Choi, PhD, Adjunct Assistant Professor

Specialty:  Research & Development

Thermo Fisher Scientific

 

Surbhi Desai, PhD, Adjunct Instructor

Specialty:  Immunology, Proteomics

Thermo Fisher Scientific

 

Joshua Edwards, PhD, Adjunct Instructor

Specialty:  Pharmacology

Midwestern University

 

Megan Fleischmann, PharmD

Specialty:  Pharmacology

University of Illinois College of Medicine at Rockford, Family Health Center

 

Lawrence D. Frenkel, MD, Adjunct Professor

Specialty:  Microbiology

Georgetown University School of Medicine

 

Keith Glaser, PhD, Adjunct Professor

Specialty:  Drug Development

Abbott Laboratories

 

Wade Green, PhD, Adjunct Instructor

Specialty:  Entrepreneur Start-up, Intellectual Property

Office of Technology Management, University of Illinois at Chicago

 

Leslyn Hanakahi, PhD, Adjunct Assistant Professor

Specialty:  Molecular Biophysics, Biochemistry

Department of Pharmacy, University of Illinois at Chicago

 

Paul Haney, PhD, Adjunct Instructor

Specialty:  Cell Biology, Biochemistry

Thermo Fisher Scientific

 

Rita Highland, RN, Adjunct Instructor

Specialty:  Clinical Lab Instruction

SwedishAmerican – A Division of UW Health

 

Scott Homann, MD, Associate Professor

Specialty:  Infectious Disease

University of Illinois College of Medicine at Rockford

Rockford Infectious Disease

 

Rohit Kolhatkar, PhD, Adjunct Assistant Professor

Specialty:  Drug Delivery, Nanotechnology

Department of Pharmacy, University of Illinois at Chicago

 

N. Martin MacDowell, Jr., Research Associate Professor

Specialty:  National Center for Rural Health Professionals

University of Illinois College of Medicine at Rockford, Department of Family and Community Medicine

 

John Nitiss, PhD, Adjunct Professor

Specialty:  Anticancer, Therapeutics and Imaging

University of Illinois College of Pharmacy at Rockford

 

Marie Nlend, PhD, Adjunct Instructor

Specialty:  Immunohistochemistry

Thermo Fisher Scientific

 

Richard Olson, MD, Adjunct Instructor

Specialty:  Clinical Research

Rockford Orthopedic Associates

 

Ray Ortiz, HT (ASCP), QIHC

Specialty:  Immunohistochemistry

MercyRockford Health System

 

Jacob Peuler, PhD, Adjunct Professor

Specialty:  Pharmacology

Midwestern University

 

Walter Prozialeck, PhD, Adjunct Research Professor

Specialty:  Pharmacology

Midwestern University

 

Kianoush Sheykholeslami, MD, PhD, Adjunct Assistant Professor

Specialty: Neuroscience, Head/Neck Surgery

MercyRockford Health System

 

Troy Skwor, PhD., Adjunct Instructor

Specialty:  Chemical/Biological Research

Rockford University

 

Thomas Smith, PhD, Adjunct Instructor

Specialty:  Biostatistics

Northern Illinois University

 

James Stim, MD, Adjunct Assistant Professor

Specialty:  Pharmacology

Rockford Nephrology Associates

 

James Sturm, MD, Adjunct Instructor

Specialty:  Anesthesiology, Pharmacology

MercyRockford Health System

 

Lindsey Tompkins, MS

Specialty:  IRB Statistics

Rockford Cardiovascular Associates

 

Geoffrey Tsaras, MD, Adjunct Clinical Instructor

Specialty:  Infectious Disease

Rockford Infectious Disease

 

Michael Tyrkus, PhD, Adjunct Instructor

Specialty:  Cytogenetics

MercyRockford Heath System

 

Krishna Vattem, PhD, Adjunct Instructor

Specialty:  Molecular Biology

Thermo Fisher Scientific

 

Kapila Viges, PhD, Adjunct Instructor

Specialty:  Entrepreneur Start-up

EnterpriseWorks, University of Illinois at Chicago

 

Brian Webb, PhD, Adjunct Professor

Specialty:  Molecular Biology

Thermo Fisher Scientific