Ramaswamy Kalyanasundaram DVM, PhD » MBT Faculty and Staff

Ramaswamy Kalyanasundaram DVM, PhD » MBT Faculty and Staff 2017-08-25T11:54:21+00:00

Ramaswamy Kalyanasundaram DVM, PhD

Professor & Head University of Illinois College of Medicine RockfordBiomedical Science
Work 1601 Parkview Avenue Rockford IL 61107 Work Phone: 815-395-5696Work Fax: 815-395-5684 Website: Full publication list
Photo of Ramaswamy Kalyanasundaram DVM, PhD

Biographical Info

Vaccine development and functional proteomics

Ramaswamy Kalyanasundaram DVM, PhD
Professor & Head

Research in Dr. Ramaswamy’s laboratory focuses mainly on two major areas; (1) development of a vaccine against lymphatic filariasis a tropical parasitic infection that causes a gruesome and disfiguring condition in human. According to WHO currently more than 120 million people living in 83 different countries are infected with this mosquito transmitted disease. Second major research focus is on gene mining and functional proteomics of schistosome and lymphatic filarial parasites.

Several vaccine candidates of the lymphatic filarial organism were identified in our laboratory using a phage-display cDNA expression library screening approach. Each of the candidate antigens was tested for their efficacy to confer protection against a challenge infection with Brugia malayi in experimental animals. After extensive testing, five candidate antigens ALT-2, Hsp12.6, VAL-1, GST and TSP are down selected to develop further as a multivalent vaccine. A DNA prime protein boost vaccine strategy gave the best results. Studies are underway to test the most promising vaccine formulation in non-human primates.

Under the gene mining project, we identified more than 40 new functional genes from schistosomes and filarial organisms. Our focus in this area is mainly to characterize host modulatory molecules that are novel drug targets, novel therapeutic agents and/or potential vaccine candidates.

Select publications:

Chen, L., He, YX., Rao, KVN, and Ramaswamy, K. (2002) Skin-stage schistosomula of Schistosoma mansoni secrete an apoptosis-inducing factor that can cause apoptosis of T cells. Journal of Biological Chemistry 277, 34329-34335.PMID: 12107158

Gnanasekar, M., Rao, KVN., Mishra, P., He, YX., Nutman, T., Kaliraj, P., and Ramaswamy, K. (2004) A novel phage display based screening to identify potential vaccine candidate antigens of the filarial parasite Brugia malayi. Infection and Immunity. Aug; 72(8):4707-15.PMID: 15271932

Gnanasekar, M., Anandharaman, V., Anand, S.B., Nutman, T.B., and Ramaswamy, K. (2008) “A novel small heat shock protein 12.6 (HSP12.6) from Brugia malayi functions as a human IL-10 receptor binding protein”. Molecular and Biochemical Parasitology159: 98–103.PMID: 18395809

Veerabathran A, Gajalakshmi, D, Gnanasekar, M., Reddy M.V. and Ramaswamy K. (2009) Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis. PLOS Neglected Tropical Diseases. Jun 9; 3(6):e457.PMID: 19513102.

Abhilash S, Gajalakshmi D, Ramaswamy K (2010) Multivalent Vaccine for Lymphatic Filariasis. Procedia in Vaccinology, Volume 3, 2010, Pages 12-18, DNA Vaccines 2010

Categories: Biomedical Science
Updated 3 months ago.

Department of Biomedical Science Staff

Biomedical Department Scientists

Aoshuang Chen, PhD, Associate Professor, aoshuang@uic.edu

Ramaswamy Kalyanasundaram, DVM, PhD, Professor, ramswamy@uic.edu

Xue-Jun (June) Li, PhD, Associate Professor, xjli23@uic.edu

Mathew Mathew, PhD, Associate Professor, mtmathew@uic.edu

Gnanasekar Munirathiam, Associate Professor, mgnanas@uic.edu

Karin Nitiss, Research Associate Professor, knitiss@uic.edu

Neelu Puri, Associate Professor, neelupur@uic.edu

Guoxing Zheng, Associate Professor, guoxingz@uic.edu

 

Department of Biomedical Sciences Administrative Staff

Department Head

Ramaswamy Kalyanasundaram, DVM, PhD ramaswamy@uic.edu
Professor and Head, Department of Biomedical Sciences

 

Biomedical Sciences Administration

Nancy Olson, Business Manager
nanolson@uic.edu

Janet Stull Snow, Program Administrative Assistant
jlss@uic.edu

 

Research Support

Andrew Canciamille, acanci2@uic.edu

Jessica Gorman, jgorma2@uic.edu

Joseph Orthoefer, DVM, josepho@uic.edu

Laura Sykaluk, Research Technologist, lsykal2@uic.edu

 

Master in Medical Biotechnology Program Administration

Khalifah Sidik, PhD, Director, khsidik@uic.edu

Sarah Hays, Assistant Director, sarhays@uic.edu

Wendy Schultz, site-specific Registrar functions, wschultz@uic.edu

 

Adjunct Faculty

Deborah Breiter, PhD, Adjunct Instructor

Specialty:  Immunology, Cell Biology, Biochemistry

Rockford University

 

Ryan Bomgarden, PhD, Adjunct Instructor

Specialty:  Molecular Biology, Cell Biology

Thermo Fisher Scientific

 

E. Thomas Carey, PharmD, Adjunct Instructor

Specialty:  Pharmacology

SwedishAmerican – A Division of UW Health

 

Isaac Cha, PharmD, Clinical Assistant Professor

Specialty:  Pharmacology

University of Illinois College of Medicine at Chicago

University of Illinois College of Pharmacy at Rockford

 

Jae Choi, PhD, Adjunct Assistant Professor

Specialty:  Research & Development

Thermo Fisher Scientific

 

Surbhi Desai, PhD, Adjunct Instructor

Specialty:  Immunology, Proteomics

Thermo Fisher Scientific

 

Joshua Edwards, PhD, Adjunct Instructor

Specialty:  Pharmacology

Midwestern University

 

Megan Fleischmann, PharmD

Specialty:  Pharmacology

University of Illinois College of Medicine at Rockford, Family Health Center

 

Lawrence D. Frenkel, MD, Adjunct Professor

Specialty:  Microbiology

Georgetown University School of Medicine

 

Keith Glaser, PhD, Adjunct Professor

Specialty:  Drug Development

Abbott Laboratories

 

Wade Green, PhD, Adjunct Instructor

Specialty:  Entrepreneur Start-up, Intellectual Property

Office of Technology Management, University of Illinois at Chicago

 

Leslyn Hanakahi, PhD, Adjunct Assistant Professor

Specialty:  Molecular Biophysics, Biochemistry

Department of Pharmacy, University of Illinois at Chicago

 

Paul Haney, PhD, Adjunct Instructor

Specialty:  Cell Biology, Biochemistry

Thermo Fisher Scientific

 

Rita Highland, RN, Adjunct Instructor

Specialty:  Clinical Lab Instruction

SwedishAmerican – A Division of UW Health

 

Scott Homann, MD, Associate Professor

Specialty:  Infectious Disease

University of Illinois College of Medicine at Rockford

Rockford Infectious Disease

 

Rohit Kolhatkar, PhD, Adjunct Assistant Professor

Specialty:  Drug Delivery, Nanotechnology

Department of Pharmacy, University of Illinois at Chicago

 

N. Martin MacDowell, Jr., Research Associate Professor

Specialty:  National Center for Rural Health Professionals

University of Illinois College of Medicine at Rockford, Department of Family and Community Medicine

 

John Nitiss, PhD, Adjunct Professor

Specialty:  Anticancer, Therapeutics and Imaging

University of Illinois College of Pharmacy at Rockford

 

Marie Nlend, PhD, Adjunct Instructor

Specialty:  Immunohistochemistry

Thermo Fisher Scientific

 

Richard Olson, MD, Adjunct Instructor

Specialty:  Clinical Research

Rockford Orthopedic Associates

 

Ray Ortiz, HT (ASCP), QIHC

Specialty:  Immunohistochemistry

MercyRockford Health System

 

Jacob Peuler, PhD, Adjunct Professor

Specialty:  Pharmacology

Midwestern University

 

Walter Prozialeck, PhD, Adjunct Research Professor

Specialty:  Pharmacology

Midwestern University

 

Kianoush Sheykholeslami, MD, PhD, Adjunct Assistant Professor

Specialty: Neuroscience, Head/Neck Surgery

MercyRockford Health System

 

Troy Skwor, PhD., Adjunct Instructor

Specialty:  Chemical/Biological Research

Rockford University

 

Thomas Smith, PhD, Adjunct Instructor

Specialty:  Biostatistics

Northern Illinois University

 

James Stim, MD, Adjunct Assistant Professor

Specialty:  Pharmacology

Rockford Nephrology Associates

 

James Sturm, MD, Adjunct Instructor

Specialty:  Anesthesiology, Pharmacology

MercyRockford Health System

 

Lindsey Tompkins, MS

Specialty:  IRB Statistics

Rockford Cardiovascular Associates

 

Geoffrey Tsaras, MD, Adjunct Clinical Instructor

Specialty:  Infectious Disease

Rockford Infectious Disease

 

Michael Tyrkus, PhD, Adjunct Instructor

Specialty:  Cytogenetics

MercyRockford Heath System

 

Krishna Vattem, PhD, Adjunct Instructor

Specialty:  Molecular Biology

Thermo Fisher Scientific

 

Kapila Viges, PhD, Adjunct Instructor

Specialty:  Entrepreneur Start-up

EnterpriseWorks, University of Illinois at Chicago

 

Brian Webb, PhD, Adjunct Professor

Specialty:  Molecular Biology

Thermo Fisher Scientific