Projects

Dissecting the neuron-glia crosstalk in stem cell-based models of hereditary spastic paraplegias (HSP).
Modeling recessive forms of HSP using patient-specific induced pluripotent stem cells.
Establishing motor neuron reporters to study the development of human motor neurons.
Determining motor neuron-specific degeneration in human stem cell models of spinal muscular atrophy.
Identifying mechanisms underlying axonal generation and promoting nerve regeneration.

UIC-UNAM Collaborative grant: ($20K, co-I, 2024-25)

CHA-OSF Grant: ($100K-PI, 2024-25)

NIH R01 grant: ($2M-R01 DE031832, M-PI)

10/1/2020 ~ 9/30/2025
Multidimensional Microfluidic Salivary Sensor with Adversarial Knowledge Distillation for Point-of-Care Assessment of Periodontitis and Comorbidities

NIH R56 grant: ($400K-R56 AR070181, M-PI)

10/1/2022 ~ 9/30/2024
Project Title: Corrosion Induced Hip Implant Failure: Synergistic Interactions of Patient, Materials, Surgical factors. The proposed project is to understand the role of microstructure on corrosion-induced hip implant failure.

UIC-Office of Technological Management (OTM) Pilot award: ($25K, PI, 2023-24)

UIC-UNAM Collaborative grant: ($20K, PI, 2022-23)

OTM Pilot award: ($25K, Co-PI, 2020-21)

Project Title: Urine based Electrochemical Biosensor for the breast cancer research.

NIH RO1 grant: ($3M, R01 AR070181, M-PI, 2016-22)

Project Title: Corrosion Induced Hip Implant Failure: Synergistic Interactions of Patient, Materials, Surgical factors. The proposed project is to understand the role of microstructure on corrosion-induced hip implant failure.

NIH RO3 grant: AR064005 ($100K, PI, 2019-22)

Project Title: The role of degradation products (DPs) on alteration of DNA replication and repair mechanism in neural cell environment: Toxicology aspects, The proposed project is to understand the nanoparticle toxicity caused by hip implants

IADR Research grant: ($2K, Co-PI, 2020-21)

UIC-Office of Technological Management (OTM) Pilot award: ($30K, Co-PI, 2020-21)

Project Title: Developing an electrochemical tool to eradicate the bacteria during the root canal treatment

Illinois Innovation Network (IIN) grant: ($20K, Co-PI, 2021-22)

Microport-Orthopedics: ($10K, PI, 2020-21)

NSF grant: ($300K, NSF FDN 1160951, Co-PI, 2012-16)

Project Title: Collaborative Research: Tribo-chemically Induced Gelation and Film Formation at Metal Interfaces. The proposed project is a collaborative effort aimed at understanding the formation of mechanically robust coatings at metal surfaces due to the combined action of both mechanical and electrochemical driving force.

NIH RO3 grant: ($100K, R03 AR064005, PI, 2012-16)

Project Title: Tribocorrosion in Modular Hip Joint Junctions-A Parametric Mechanistic Study.The proposed project is to understand the fretting-corrosion mechanisms at the modular junction of metal-based hip implants.

AJTMS (The American Society of Temporomandibular Surgeon) foundation grant: ($5K, Co-PI, 2013-15)

Project Title: Adopting Tribocorrosion science from the Hip implant to TMJ (Temporomandibular Joint). The proposed project is to understand the tribocorrosion mechanisms in a TMJ joint and comparison with Hip implants.

Rush Internal grant (RTSC), ($50K, Co-I, 2014-16)

Project Title: Corrosion in modular hip implants: Identifying the ideal alloy microstructure.

NIH RC2 grant: ($1.2M, RC2 AR058993, Co-I, 2009-12)

Project Title: Biotribolayer formation in metal-on-metal (MoM) hip joints. To demonstrate that the presence of a mechanically mixed zone will beneficially affect the corrosion and tribocorrosion behavior of the cobalt-chromium alloy.

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