Gnanasekar Munirathinam, PhD

Associate Professor University of Illinois College of Medicine RockfordBiomedical Sciences
Work 1601 Parkview Avenue, Rockford Rockford IL 61107 Work Phone: 815-395-5773 Work Fax: 815-395-5666 Website: Publications in PubMed Website: Dr. Gnanasekar’s CV/biosketch
Photo of Gnanasekar Munirathinam PhD

Biographical Info

Prostate Cancer Research, Functional Genomics and Proteomics

Dr. Gnanasekar’s research focus includes:
1) Chemoprevention of prostate cancer
2) Gene therapy for prostate cancer
Dr. Gnanasekar’s laboratory investigates therapeutic potential of several plant products and their derivatives.
He is also interested in screening specific genes that are selectively up regulated in human prostate cancer cells and evaluate the effects of knocking down these genes as an approach to treat prostate cancer.

Selected Publications:

Chen, A., Geng, Y., Ke, H., Constant, L., Yan, Z., Pan, Y., Lee, P., Tan, I., Williams, K., George, S., Munirathinam ,G., Reardon, C. A., Getz, G. S., Wang, B., Zheng, G. (2014). Cutting edge: Dexamethasone potentiates the responses of both regulatory T cells and B-1 cells to antigen immunization in the ApoE(-/-) mouse model of atherosclerosis. Journal of Immunology (Baltimore, Md.: 1950), 193(1), 35-39. doi:10.4049/jimmunol.1302469 [doi]

Chou, S. H., Shetty, A. V., Geng, Y., Xu, L., Munirathinam, G., Pipathsouk, A., Tan, I., Morris, T., Wang, B., Chen, A., Zheng, G. (2013). Palmitate-derivatized human IL-2: A potential anticancer immunotherapeutic of low systemic toxicity. Cancer Immunology, Immunotherapy : CII, 62(3), 597-603. doi:10.1007/s00262-012-1364-8 [doi]

Samykutty, A., Shetty, A. V., Dakshinamoorthy, G., Bartik, M. M., Johnson, G. L., Webb, B., Zheng, G., Chen, A., Kalyanasundaram, R., Munirathinam, G. (2013). Piperine, a bioactive component of pepper spice exerts therapeutic effects on androgen dependent and androgen independent prostate cancer cells. PloS One, 8(6), e65889. doi:10.1371/journal.pone.0065889 [doi]

Shetty, A. V., Thirugnanam, S., Dakshinamoorthy, G., Samykutty, A., Zheng, G., Chen, A., Bosland, M. C., Kajdacsy-Balla, A., Munirathinam, G. (2011). 18alpha-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes. International Journal of Oncology, 39(3), 635-640. doi:10.3892/ijo.2011.1061 [doi]

Srinivasan, M., Banerjee, S., Palmer, A., Zheng, G., Chen, A., Bosland, M. C., Kajdacsy-Balla, A., Kalyanasundaram, R., Munirathinam, G. (2014). HMGB1 in hormone-related cancer: A potential therapeutic target. Hormones & Cancer, 5(3), 127-139. doi:10.1007/s12672-014-0175-0 [doi]

Categories: Biomedical Sciences