Mathew Mathew, PhD, the Cedric W. Blazer Endowed Professor of Biomedical Sciences and director of faculty research in the Office of Research, received a University of Illinois Chicago Chancellor’s Translational Research Initiative Award from the UIC Vice Chancellor for Innovation and the Office of Technology Management. The award will fund the further development of an electrochemical biosensor (ENI-Biosens) for pancreatic cancer that Dr. Mathew and his team are developing in the Regenerative Medicine and Disability Laboratory, where he is co-director. Co-investigators of this project are Hemalatha Kanniyappan, PhD, a postdoctoral researcher in Dr. Mathew’s lab; Gnanaseker Munirathinam, PhD, an associate professor in the Molecular Oncology Lab of the Department of Biomedical Sciences; VK Gadi, MD, PhD, a professor and director of medical oncology in the UICOMC Department of Medicine and deputy-director, UI Cancer Center; and Amit Trivedi, PhD, an associate professor in the UIC College of Engineering’s Department of Electrical and Computer Engineering.
In this proposed work, the researchers would like to extend the sensor modalities of pancreatic cancer protein biomarkers and include CA 242 for a more accurate pancreatic cancer risk evaluation. Moreover, the distinctiveness of the technology is that fabricated biosensors would be used as a point-of-care device, like a glucometer test for diabetic patients, at home by the patient or ordinary people before clinical/invasive tests to provide early warnings on pancreatic cancer. A Machine Learning (ML) model will be formulated using Python module software, and an algorithm will be used to make precise risk level predictions for early pancreatic cancer diagnosis.