Gnanasekar Munirathinam, PhD
Associate Professor (RT)
Department of Biomedical Sciences
Contact
Address:
1601 Parkview Avenue, Rockford, Rockford, IL 61107
Email:
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About
Prostate Cancer Research, Functional Genomics and Proteomics
Dr. Gnanasekar’s research focus includes:
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- Chemoprevention of prostate cancer
- Gene therapy for prostate cancer
Dr. Gnanasekar’s laboratory investigates therapeutic potential of several plant products and their derivatives.
He is also interested in screening specific genes that are selectively up regulated in human prostate cancer cells and evaluate the effects of knocking down these genes as an approach to treat prostate cancer.
Selected Publications
Chen, A., Geng, Y., Ke, H., Constant, L., Yan, Z., Pan, Y., Lee, P., Tan, I., Williams, K., George, S., Munirathinam ,G., Reardon, C. A., Getz, G. S., Wang, B., Zheng, G. (2014). Cutting edge: Dexamethasone potentiates the responses of both regulatory T cells and B-1 cells to antigen immunization in the ApoE(-/-) mouse model of atherosclerosis. Journal of Immunology (Baltimore, Md.: 1950), 193(1), 35-39. doi:10.4049/jimmunol.1302469 [doi]
Srinivasan, M., Banerjee, S., Palmer, A., Zheng, G., Chen, A., Bosland, M. C., Kajdacsy-Balla, A., Kalyanasundaram, R., Munirathinam, G. (2014). HMGB1 in hormone-related cancer: A potential therapeutic target. Hormones & Cancer, 5(3), 127-139. doi:10.1007/s12672-014-0175-0 [doi]
Chou, S. H., Shetty, A. V., Geng, Y., Xu, L., Munirathinam, G., Pipathsouk, A., Tan, I., Morris, T., Wang, B., Chen, A., Zheng, G. (2013). Palmitate-derivatized human IL-2: A potential anticancer immunotherapeutic of low systemic toxicity. Cancer Immunology, Immunotherapy : CII, 62(3), 597-603. doi:10.1007/s00262-012-1364-8 [doi]
Samykutty, A., Shetty, A. V., Dakshinamoorthy, G., Bartik, M. M., Johnson, G. L., Webb, B., Zheng, G., Chen, A., Kalyanasundaram, R., Munirathinam, G. (2013). Piperine, a bioactive component of pepper spice exerts therapeutic effects on androgen dependent and androgen independent prostate cancer cells. PloS One, 8(6), e65889. doi:10.1371/journal.pone.0065889 [doi]
Shetty, A. V., Thirugnanam, S., Dakshinamoorthy, G., Samykutty, A., Zheng, G., Chen, A., Bosland, M. C., Kajdacsy-Balla, A., Munirathinam, G. (2011). 18alpha-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes. International Journal of Oncology, 39(3), 635-640. doi:10.3892/ijo.2011.1061 [doi]