Publications
Publications
Principal Investigator Xue-Jun (June) Li, PhD
Li XJ, Du ZW, Zarnowska ED, Pankratz M, Hansen LO, Pearce RA, Zhang SC. Specification of motoneurons from human embryonic stem cells. Nature Biotechnology. 2005, 23: 215-221.
Zhang SC, Li XJ, Johnson MA, Pankratz M. Human embryonic stem cells for brain repair (review). Philosophical Transactions: Biological Sciences. 2008, 363:87-99.
Chamberlain SJ, Li XJ, Lalande M. Induced pluripotent stem (iPS) cells as in vitro models of human neurogenetic disorders (review). Neurogenetics. 2008, 9:227-235.
Li XJ, Hu BY, Jones SA, Zhang YS, LaVaute TM, Du ZW, Zhang SC. Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells. 2008, 26:886-893.
Li XJ*, Zhang X, Johnson MA, Wang ZB, LaVaute TM, Zhang SC. Coordination of Sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. Development. 2009, 136: 4055-4063.
Zeng H, Guo M, Martins-Taylor K, Wang XF, Zhang Z, Park JW, Zhan SN, Kronenberg MS, Lichtler A, Liu HX, Chen FP, Yue L, Li XJ*, Xu RH*. Specification of Region-specific Neurons Including Forebrain Glutamatergic Neurons from Human Induced Pluripotent Stem Cells. PLoS One. 2010, 5 (7):e11853 (*Corresponding author; > 230 Citations, Google Scholar, 01/2024).
Wang ZB, Boisvert E, Zhang X, Guo M, Fashoyin A, Du ZW, Zhang SC, Li XJ*. Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells. Cerebral cortex. 2011, 21:2177-2186. (*Corresponding author).
Wang ZB, Zhang X, and Li XJ*. Recapitulation of spinal motor neuron-specific disease phenotypes in a human cell model of spinal muscular atrophy. Cell Research. 2013, 23(3):378-93. doi: 10.1038/cr.2012.166.
Boisvert E, Denton K, Lei L, Li XJ*. Specification of telencephalic glutamatergic neurons from human pluripotent stem cells. Journal of Visualized Experiments. 2013, 74. doi: 10.3791/50321.
Denton K, Lei L, Grenier J, Rodionov V, Blackstone C, Li XJ*. Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia. Stem Cells. 2014, 232(2):414-23. doi: 10.1002/stem.1569. (*Corresponding author; 131 Citations, Google Scholar, 01/2024).
Zhu PP, Denton K, Renvoise B, Pierson TM, Li XJ*, Blackstone C. Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A. Human Molecular Genetics. 2014, 23(21):5638-48. doi: 10.1093/hmg/ddu280 (*Corresponding author; 64 Citations, Google Scholar, 01/2024).
Denton K, Xu CC, Li XJ*. Modeling axonal phenotypes with human pluripotent stem cells. Methods Mol. Biol. 2014, doi:10.1007/7651_2014_167. (*Corresponding author).
Chen T, Xiang JF, Zhu S, Chen S, Yin QF, Zhang XO, Zhang J, Feng H, Li XJ, Yang Li, Chen LL. ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner. Cell Research. 2015, 25(4):459-76. doi: 10.1038/cr.2015.24.
Liu HS, Lu JF, Chen H, Du ZW, Li XJ, Zhang SC. Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability. Scientific Report. 2015 Jul 20; 5:12189. doi: 10.1038/srep12189.
Boisvert EM, Engle SJ, Hallowell SE, Liu P, Wang ZW, Li XJ*. The specification and maturation of nociceptive neurons from human embryonic stem cells. Scientific Reports. 2015, 5: 16821; doi: 10.1038/srep16821 (* Corresponding Author).
Xu CC, Denton KR, Wang ZB, Zhang X, Li XJ*. Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy. Disease Models & Mechanisms. 2016, 9(1):39-49. doi: 10.1242/dmm.021766. (* Corresponding Author; 71 Citations, Google Scholar, 01/2024).
Liu L, Yuan H, Denton K, Li XJ, McCullough L, Li J. Calcium/Calmodulin-Dependent Protein Kinase Kinase β (CaMKK β) is Neuroprotective in Stroke in Aged Mice. European Journal of Neuroscience. 2016, 44(4):2139-46.
Denton KR, Xu CC, Shah H, Li XJ*. Modeling Axonal Defects in Hereditary Spastic Paraplegia with Human Pluripotent Stem Cells (Invited Review). Frontiers in Biology. 2016, 11(5):339-354. (*Corresponding Author).
Denton KR, Mou YC, Xu CC, Shah D, Chang J, Blackstone C, Li XJ*. Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias. Human Molecular Genetics, 2018, 15: 2517-2530 doi: 10.1093/hmg/ddy156. (*Corresponding Author; 42 Citations, Google Scholar, 01/2024).
Bijukumar D, Segu A, Mou Y, Ghodsi SM, Shokufhar T, Barba M, Li XJ, Mathew MT. Differential toxicity of processed and non-processed states of CoCrMo degradation products generated from a hip simulator on neural cells. Nanotoxicity. 2018, 25:1-16. doi: 10.1080/17435390.
Pattali R, Mou Y, Li XJ*. AAV9 Vector: a Novel modality in gene therapy for spinal muscular atrophy (Review Article). Gene Therapy. 2019, 26:287-295. PMID: 31243392. (*Corresponding Author; 83 Citations, Google Scholar, 01/2024).
Wang YR, Xu CC, Mou YC, Zhang BW, Tian Y, Ma L, Trinh J, Zhang XQ, Li XJ*. Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology. Life Sci Alliance. 2019, 2(2). pii: e201800268. doi: 10.26508/lsa.201800268 (* Corresponding Author).
Mou Y, Mukte S, Chai E, Dein J, Li XJ*. Analyzing mitochondrial transport and morphology in human induced pluripotent stem cells-derived forebrain neurons in hereditary spastic paraplegia. The Journal of Visualized Experiments. 2020 (156). doi: 10.3791/60548. (*Corresponding Author).
Mou Y, Dong Y, Chen Z, Denton K, Duff M, Blackstone C, Zhang SC, Li XJ*. Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia. Acta Neuropathologica Communications. 2020, 8: 214. (*Corresponding Author; 22 Citations, Google Scholar, 01/2024).
Li XJ*, Mou Y, Milton C, Chen ZY. Monitoring Axonal Degeneration in Human Pluripotent Stem Cell Models of Hereditary Spastic Paraplegias. Methods in Molecular Biology. Invited Chapter for iPS Cells and Disease Models: Methods and Protocols. 2021, doi: 10.1007/7651_2021_379. (*Corresponding Author).
Karpe Y, Chen ZY, Li XJ*. Stem cell models and gene targeting for human motor neuron diseases (Review Article). Pharmaceuticals. 2021, 14(6):565. doi: 10.3390/ph14060565.
Mou Y, Dein J, Chen ZY, Jagdale M, Li XJ*. MFN2 Deficiency Impairs Mitochondrial Transport and Downregulates Motor Protein Expression in Human Spinal Motor Neurons. Frontiers in Molecular Neuroscience. 2021 Sep 16;14:727552. doi: 10.3389/fnmol.2021.727552. (*Corresponding Author).
Li XJ*. Non-cell autonomous role of astrocyte in axonal degeneration of cortical projection neurons in hereditary spastic paraplegias. Neural Regeneration Research. Invited Perspective. 2022,17(6):1265-1266. doi: 10.4103/1673-5374.327342.
Chen ZY, Chai E, Mou YC, Roda RH, Blackstone C, Blackstone C*, Li XJ*. Inhibiting mitochondrial fission rescues degeneration in hereditary spastic paraplegia neurons. Brain. 2022: Nov 21;145(11):4016-4031. doi: 10.1093/brain/awab488. (*Corresponding Author; 14 Citations, Google Scholar, 01/2024).
Mou Y, Nandi G, Mukte S, Chai E, Chen Z, Nielsen JE, Nielsen TT, Criscuolo C, Blackstone C, Fraidakis MJ, Li XJ*. Chenodeoxycholic acid rescues axonal degeneration in induced pluripotent stem cell-derived neurons from spastic paraplegia type 5 and cerebrotendinous xanthomatosis patients. Orphanet Journal of Rare Diseases. 2023 Apr 6;18(1):72 (*Corresponding Author).
Chai E, Chen Z, Mou Y, Thakur G, Zhan W, Li XJ*. Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking. Neurobiology of Disease. 2023 Oct 15:187:106293. doi: 10.1016/j.nbd.2023.106293. (*Corresponding Author).
Chen Z, Li XJ*. Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia. Neural Regeneration Research, in press.
Principal Investigator Xue-Jun (June) Li, PhD, Publications
Principal Investigator Mathew T. Mathew, PhD
Souza JCM, Tajiri HA, Morsch CS, Buciumeanu M, Mathew MT, Silva FS, Henriques B. TLee. C, Zhang L, Cheng KY, Ramachandran RA, Barba M, Ozevin D, Mathew MT. Non-invasive early detection of failure modes in total hip replacements (THR) via acoustic emission AE, Journal of Mechanical Behavior of Biomedical Materials, 118, 104484, 2021
Barão VAR, Ramachandran RM, Matos AO, Badhe RV, Grandini CR, Sukotjo C, Ozevin D, Mathew MT. Prediction of tribocorrosion processes in titanium-based dental implants using acoustic emission technique: Initial outcome, Materials Science and Engineering: C (2021): 112000, 2021
Radzik BL, Cheng KY, Badhe R, Bijukumar DR, Barba ML, Mathew MT. The role of Fretting-frequency on the damage modes of THR Modular Junction: In-vitro study, Materials Science and Engineering: C (2021): 112128. 2021,
Zamperini CA, Padron AC, Villanueva J, Mathew MT, Bedran-Russo AK. In vitro anti-erosive property of a mint containing bioactive ingredients., American Journal of Dentistry 34 (4), 191-194, (2021)
McCarthy SM, Hall DJ, Mathew MT, Jacobs JJ, Lundberg HL, Pourzal R. Are damage modes related to microstructure and material loss in severely damaged CoCrMo femoral heads?, Clinical Orthopaedics and Related Research, 479 (9), 2083-2096, (2021)
Badhe RV, Akinfosile O, Bijukumar D, Barba M, Mathew MT, Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices–A mini review, Toxicology Letters 350, 213-224, (2021)
Manjunath V, Badhe RV, McCoy M, Rynne J, Bhatti A, Segu A, Oral E, Jacobs JJ, Chastain P II, Bijukumar D, Mathew MT. The role of Vitamin E in hip implant-related corrosion and toxicity: Initial outcome, JMBBM, Volume 123, November 2021, 104769,
Costa RC, Abdo VL, Mendes PHC, Mota-Veloso I, Bertolini M, Mathew MT, Barão VAR, Souza JGS, Microbial Corrosion in Titanium-Based Dental Implants: How Tiny Bacteria Can Create a Big Problem?, Journal of Bio-and Tribo-Corrosion 7 (4), 1-22, (2021)
Badhe RV, Bijukumar D, Mesquita P, Cheng KY, Ramachandran RM, Lin Y, Mathew MT, Dynamic microfluidic bioreactor—Hip simulator (DMBH) system for implant toxicity monitoring, Biotechnology and Bioengineering 118 (12), 4829-4839, (2021)
Ramachandran RA, Barão VAR, Matos AO, Cordeiro JM, Grandini CR, Sukotjo C, Mathew MT, Suitability of Ti–Zr Alloy for Dental Implants: Tribocorrosion Investigation, Journal of Bio-and Tribo-Corrosion 7 (4), 1-15, (2021)
Xu A, Alhamad M, Ramachandran RA, Shukla A, Barão VA, Sukotjo C, Mathew MT, Peri-Implantitis in Relation to Titanium Corrosion: Current Status and Future Perspectives, Journal of Bio-and Tribo-Corrosion 8 (2), 1-17 (2022)
Fischer D, Cheng KY, Neto MQ, Hall DJ, Bijukumar D, Espinoza Orías AA, Pourzal R, Arkel RJ, Mathew MT, Corrosion Behavior of Selective Laser Melting (SLM) Manufactured Ti6Al4V Alloy in Saline and BCS Solution. Journal of Bio-and Tribo-Corrosion 8 (2), 1-14 (2022)
Manthe J, Cheng KY, Bijukumar D, Barba M, Pourzal R, Neto M, Mathew MT, Hip implant modular junction: The role of CoCrMo alloy microstructure on fretting-corrosion, Journal of the Mechanical Behavior of Biomedical Materials, Volume 134, October 2022, 105402, https://doi.org/10.1016/j.jmbbm.2022.105402
Xu A, Alhamad M, Ampadi Ramachandran R, Shukla A, Barão VA, Sukotjo C, Mathew MT. Peri-Implantitis in Relation to Titanium Corrosion: Current Status and Future Perspectives. Journal of Bio-and Tribo-Corrosion. 2022 Jun;8(2):1-7.
Ampadi Ramachandran R, Chi SW, Srinivasa Pai P, Foucher K, Ozevin D, Mathew MT, Artificial intelligence and machine learning as a viable solution for hip implant failure diagnosis—Review of literature and in vitro case study, Med. Biol. Eng. Computer. 61 (2023) 1239–1255. https://doi.org/10.1007/s11517-023-02779-1.
Badhe RV, Chatterjee A, Bijukumar D, Mathew MT, Current advancements in bio-ink technology for cartilage and bone tissue engineering, Bone. 171 (2023) 116746. https://doi.org/10.1016/j.bone.2023.116746.
Borges M.H.R., Nagay BE, Costa RC, Souza JGS, Mathew MT, Barão VAR, Recent advances of polypyrrole conducting polymer film for biomedical application: Toward a viable platform for cell-microbial interactions, Adv. Colloid Interface Sci. 314 (2023) 102860. https://doi.org/10.1016/j.cis.2023.102860.
Gokul D, Catton E, Cheng KY, Mathew MT, Electrochemical Biosensor to Detect Implant-Derived Metal Ions: A Mice Model, J. Bio- Tribo-Corros. 9 (2023) 28. https://doi.org/10.1007/s40735-023-00743-y.
Kumari S, Samara M, Ampadi Ramachandran R, Gosh S, George H, Wang R, Pesavento R, Mathew MT, A Review on Saliva-Based Health Diagnostics: Biomarker Selection and Future Directions, Biomed. Mater. Devices. (2023). https://doi.org/10.1007/s44174-023-00090-z.
Mathew MT, Cheng K, Sun T, Barao VAR, The Progress in Tribocorrosion Research (2010–21): Focused on the Orthopedics and Dental Implants, J. Bio- Tribo-Corros. 9 (2023) 48. https://doi.org/10.1007/s40735-023-00767-4.
Muthulakshmi L, Seghal Kiran G, Ramakrishna S, Cheng KY, Ampadi Ramachandran R, Mathew MT, Pruncu CI, Towards improving the corrosion resistance using a novel eco-friendly bioflocculant polymer produced from Bacillus sp., Mater. Today Commun. 35 (2023) 105438. https://doi.org/10.1016/j.mtcomm.2023.105438.
Świątkowska I, Akinfosile OJ, Badhe RV, Barba M, Mathew MT, Bijukumar D, Chapter 7 – Hip implants and systemic cobalt toxicity: a comprehensive review with case studies, in: I. Świątkowska (Ed.), Biomark. Hip Implant Funct., Academic Press, 2023: pp. 205–247. https://doi.org/10.1016/B978-0-12-821596-8.00007-0.
Sun Y, Cheng KY, Kanniyappan H, Ampadi Ramachandran R, Queiroz Neto M, McNallan M, Pourzal R, Lundberg H, Mathew MT, Fretting-Corrosion Apparatus with Low Magnitude Micro-motion (≤ 5 µm): Development and Preliminary Outcome., Journal of Bio and Tribo Corrosion, 2023
Cheng KY, Gupta P, Kanniyappan H, Zahurullah H, Sun Y, Alhamad M, Mathew MT., Survivability of Titanium Implant Materials: In Vitro Simulated Inflammatory and Infectious Environment. Annals of Biomedical Engineering. 51, 2749-2761(2023).
Alhamad M, Barao VAR, Sukotjo C, Yerokhin A, Mathew MT, Unpredictable Electrochemical Proceses in Ti Dental Implants: The Role of Ti ions and Inflammatory Products, ACS Applied Bio Materials, 2023, 6,9, 3661-3673.
Ampadi Ramachandran R, Li W, Khande S, Shylendra A, Trivedi AR, Xie Q, Wu CD, Mathew MT, Advanced Electrochemical Reamer (EC-Reamer) for Root Canal Treatment, European Endodontic Journal, 2023; 8:79-89.
Maged SAA, Anaee RA, Mathew MT, The Role of Uric Acid to Reduce the Corrosion of Co-Cr-Mo Alloy as Joint in Presence of Ca and Vitamin D3, Journal of Bio-and Tribo-Corrosion, Volume, 9, Issue, 4, Pages, 66
Sun Y, Kinnerk K, Mirshed T, McNallan M, Mathew MT, In vitro tribocorrosion evaluation of carbide-derived carbon (CDC) for hip implants, Structural, Functional and Bioceramics, 122.2023, 3-4.
Alharti SD, Kanniyappan H, Prithweeraj S, Bijukumar D, Mathew MT, Proteomic-based electrochemical non-invasive biosensor for early breast cancer diagnosis. International Journal of Biological Macromolecules, 253, 4,31, 126681
Borges MHR, Kanniyappan H, Sun Y, Nagay BE, Cruz N, Mathew MT, Barao VAR, Polypyrrole zinc-doped film deposited on a plasma-treated surface improves the tribocorrosion behavior of titanium dental implant material, Surface and Coatings Technology, 475, 2023, 130165
Alhamad M, Barão VAR, Sukotjo C, Mathew MT, The effect of three dental cement types on the corrosion of dental implant surfaces, Heliyon, just accepted Jan 2023
Rathnayake AC, Zhao Z, McLaughlin N, Li W, Yan Y, Chen LL, Xie Q, Wu CD, Mathew MT, Wang RR, Machine learning enabled multiplex detection of periodontal pathogens by surface-enhanced Raman spectroscopy, International Journal of Biological Macromolecules, Pages 128773,
Keaty B, Sun Y, Didem O, Eapen J, Mathew MT, Early Detection of Fretting Corrosion in Hip Replacement by Acoustic Emission Non-Invasive Technique, Thin Solid Films, Publication date, 2023/12/7
Bui, Anh Tuan, Hieu Le, Tung Thanh Hoang, Giam Minh Trinh, Hao-Chiang Shao, Pei-I. Tsai, Kuan-Jen Chen et al. “Development of End-to-End Artificial Intelligence Models for Surgical Planning in Transforaminal Lumbar Interbody Fusion.” Bioengineering 11, no. 2 (2024): 164
Kanniyappan, Hemalatha, Kai-yuan Cheng, Ravindra V. Badhe, Mozart Neto, Divya Bijukumar, Mark Barba, Robin Pourzal, and Mathew Mathew. “Investigation of cell-accelerated corrosion (CAC) on the CoCrMo alloy with segregation banding: Hip implant applications.” Journal of the Mechanical Behavior of Biomedical Materials 152 (2024): 106449.
George, Haritha, Yani Sun, Junyi Wu, Yan Yan, Rong Wang, Russell P. Pesavento, and Mathew T. Mathew. “Intelligent salivary biosensors for periodontitis: in vitro simulation of oral oxidative stress conditions.” Medical & Biological Engineering & Computing (2024): 1-26.
Sun, Yani, Kai-yuan Cheng, Hemalatha Kanniyappan, Remya Ampadi Ramachandran, Mozart Queiroz Neto, Michael McNallan, Robin Pourzal, Hannah Lundberg, and Mathew T. Mathew. “Fretting-Corrosion Apparatus with Low Magnitude Micro-motion (≤ 5 µm) for Hip Implant Taper Junctions: Development and Preliminary Outcome.” Journal of Bio-and Tribo-Corrosion 10, no. 2 (2024): 24.