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Dr. Li’s Lab Heading link

Bijukumar D, Segu A, Mou Y, Ghodsi SM, Shokufhar T, Barba M, Li XJ, Mathew MT. Differential toxicity of processed and non-processed states of CoCrMo degradation products generated from a hip simulator on neural cells. Nanotoxicity. 2018 (Accepted).

Denton KR, Mou YC, Xu CC, Shah D, Chang J, Blackstone C, Li XJ*. Restoring mitochondrial morphology rescues axonal defects in patient-derived neurons of hereditary spastic paraplegias. Human Molecular Genetics, 2018. doi: 10.1093/hmg/ddy156. [Epub ahead of print]. (*Corresponding Author).

Bijukumar D, Segu A, Souza J, Li XJ, Barba M, Mercuri L, Jacobs J, Mathew TM. Neurotoxic effect of CoCr wear particles generated from hip simulator using iPSC derived neurons: initial outcomes. J Orthop Res, 2017, 35 (S1).

Denton KR, Xu CC, Shah H, Li XJ*. Modeling Axonal Defects in Hereditary Spastic Paraplegia with Human Pluripotent Stem Cells (Invited Review). Frontiers in Biology. 2016, 11(5):339-354. (*Corresponding Author).

Liu L, Yuan H, Denton K, Li XJ, McCullough L, Li J. Calcium/Calmodulin-Dependent Protein Kinase Kinase β (CaMKK β) is Neuroprotective in Stroke in Aged Mice. European Journal of Neuroscience. 2016, 44(4):2139-46.

Yuan H, Denton K, Liu L, Li XJ, Benashski S, McCullough L, Li J. Nuclear translocation of histone deacetylase 4 (HDAC4) induces neuronal death in stroke. Neurobiology of Disease. 2016, 91:182-93.

Knowlton S, Cho YK, Li XJ, Khademhosseini A, Tasoglu S. Utilizing Stem Cells for Three-Dimensional Neural Tissue Engineering (Review Article). Biomaterials Science. 2016 May 26;4(5):768-84. doi: 10.1039/c5bm00324e. Epub 2016 Feb 18. PMID: 26890524.

Xu CC, Denton KR, Wang ZB, Zhang X, Li XJ*. Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy. Disease Models & Mechanisms. 2016 Jan 1;9(1):39-49. PubMed PMID: 26586529; PubMed Central PMCID: PMC4728333.

Denton K, Xu CC, Li XJ*. Modeling axonal phenotypes with human pluripotent stem cells. Methods Mol. Biol. 2016;1353:309-21. doi: 10.1007/7651_2014_167. PMID: 25520289.

Boisvert EM, Engle SJ, Hallowell SE, Liu P, Wang ZW, Li XJ*. The specification and maturation of nociceptive neurons from human embryonic stem cells. Scientific Reports. 2015, 5: 16821. PubMed PMID: 26581770; PubMed Central PMCID: PMC4652175.

Liu HS, Lu JF, Chen H, Du ZW, Li XJ, Zhang SC. Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability. Scientific Report. 2015 Jul 20; 5:12189. doi: 10.1038/srep12189. PMID: 26190808. PMCID: PMC4507262.

Chen T, Xiang JF, Zhu S, Chen S, Yin QF, Zhang XO, Zhang J, Feng H, Li XJ, Yang Li, Chen LL. ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner. Cell Research. 2015, 25(4):459-76. doi: 10.1038/cr.2015.24. PMID: 25708366. PMCID: PMC4387555.

Zhu PP, Denton K, Renvoise B, Pierson TM, Li XJ*, Blackstone C. Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A. Hum Mol Genet. 2014, 23(21):5638-48. doi: 10.1093/hmg/ddu280. PMID: 24908668. PMCID: PMC4189900.

Denton K, Lei L, Grenier J, Rodionov V, Blackstone C, Li XJ*. Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia. Stem Cells. 2014, 232(2):414-23. doi: 10.1002/stem.1569. PMID: 24123785. PMCID: PMC3947148.

Boisvert E, Denton K, Lei L, Li XJ*. Specification of telencephalic glutamatergic neurons from human pluripotent stem cells. Journal of Visualized Experiments. 2013, 74. doi: 10.3791/50321. PMID: 23603787. PMCID: PMC3656538.

Martins-Taylor K, Wang X, Li XJ, and Xu RH. Stem Cells and Tissue Regeneration. In:  Laurencin CT, Khan Y. eds. Regenerative Engineering, 2013 (Book Chapter).

Wang ZB, Zhang X, and Li XJ*. Recapitulation of spinal motor neuron-specific disease phenotypes in a human cell model of spinal muscular atrophy. Cell Research. 2013, 23(3):378-93. doi: 10.1038/cr.2012.166. PubMed PMID: 23208423; PubMed Central PMCID: PMC3587706.

Zhan H, Moore CS, Chen B, Zhou X, Ma XM, Ijichi K, Bennett M, Li XJ, Crocker S, Wang ZW. Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal.  PLoS ONE. 2012, 7(6):e39489. doi: 10.1371. PMID: 22768083. PMCID: PMC3387187.

Wang ZB, Boisvert E, Zhang X, Guo M, Fashoyin A, Du ZW, Zhang SC, Li XJ*. Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells. Cerebral cortex. 2011, 21:2177-2186. PubMed PMID: 21330470; PubMed Central PMCID: PMC3155607.

Zeng H, Guo M, Martins-Taylor K, Wang XF, Zhang Z, Park JW, Zhan SN, Kronenberg MS, Lichtler A, Liu HX, Chen FP, Yue L, Li XJ*, Xu RH*. Specification of Region-specific Neurons Including Forebrain Glutamatergic Neurons from Human Induced Pluripotent Stem Cells. PLoS One. 2010, 5 (7):e11853. PubMed PMID: 20686615; PubMed Central PMCID: PMC2912324.

Zhang X, Huang CT, Chen J, Pankratz MT, Xi J, Li J, Yang Y, LaVaute TM, Li XJ, Ayala M, Bondarenko GI, Du ZW, Jin Y, Golos TG, Zhang SC. Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell. 2010, 7: 90-100. PubMed PMID: 20621053; PubMed Central PMCID: PMC2904346.

Li XJ*, Zhang X, Johnson MA, Wang ZB, LaVaute TM, Zhang SC. Coordination of Sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. Development. 2009, 136: 4055-4063. PubMed PMID: 19906872; PubMed Central PMCID: PMC2778748

Zeng H, Park JW, Guo M, Lin G, Crandall L, Compton T, Wang X, Li XJ, Chen FP, Xu RH. Lack of ABCG2 Expression and Side Population Properties in Human Pluripotent Stem Cells. Stem Cells. 2009, 27:2435-2445. PubMed PMID: 19670287.

Hu BY, Du ZW, Li XJ, Ayala M, Zhang SC. Human Oligodendrocytes from Embryonic Stem Cells: Conserved SHH Signaling Networks and Divergent FGF Effects. Development. 2009, 136:1443-1452. PubMed PMID: 19363151; PubMed Central PMCID: PMC2674255.

Li XJ, Hu BY, Jones SA, Zhang YS, LaVaute TM, Du ZW, Zhang SC. Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells. 2008, 26:886-893. PubMed PMID: 18238853; PubMed Central PMCID: PMC2707816.

Chamberlain SJ, Li XJ, Lalande M. Induced pluripotent stem (iPS) cells as in vitro models of human neurogenetic disorders (review). Neurogenetics. 2008, 9:227-235. PMID: 18791750.

Li XJ, Yang DL, Zhang SC. Motoneuron and dopamine neuron differentiation. In: Loring J, Wesselschmidt R, Schwartz P. eds. Human Stem Cell Manual: a Laboratory Guide. Spiral Bound, 2008 (Book Chapter).

Zhang SC, Li XJ, Johnson MA, Pankratz M. Human embryonic stem cells for brain repair (review). Philosophical Transactions: Biological Sciences. 2008, 363:87-99. PMID: 17322002. PMCID: PMC2605488.

Pankratz MT, Li XJ, LaVaute TM, Lyons EA, Chen X, Zhang SC. Directed Neural Differentiation of hESCs via an Obligated Primitive Anterior Stage. Stem Cells. 2007, 25:1511-1520. PMID: 17332508. PMCID: PMC2743478.

Du ZW, Li XJ, Nguyen GD, Zhang SC. Induced expression of Olig2 is sufficient for oligodendrocyte specification but not for motoneuron specification and astrocyte repression. Mol. Cell. Neurosci. 2006, 33:371-380. PMID: 17035043.

Li XJ, Zhang SC. In vitro differentiation of neural precursors from human embryonic stem cells. In: Turksen K eds. Human Embryonic Stem Cell Protocols. Human Press Inc., 2006. PMID: 16881517.

Guillaume D, Johnson A, Li XJ, Zhang SC. Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. J. Neurosci. Res. 2006, 84:1165-1176. PMID: 16941479. PMCID: PMC2735209.

Li XJ, Du ZW, Zarnowska ED, Pankratz M, Hansen LO, Pearce RA, Zhang SC. Specification of motoneurons from human embryonic stem cells. Nature Biotechnology. 2005, 23: 215-221. PMID: 15685164.

Chen LJ, Gao YQ, Li XJ, Shen DH, Sun FY. Melatonin protects against MPTP/MPP+ -induced mitochondrial DNA oxidative damage in vivo and in vitro. J. Pineal Res. 2005, 39:34-42. PMID: 15978055.

Li XJ, Gu J, Lu SD, Sun FY. Melatonin attenuates MPTP-Induced dopaminergic neuronal injury associated with scavenging hydroxyl radical. J. Pineal Res. 2002, 32: 47-52. PMID: 11841600.

Li XJ, Sun FY. Molecular mechanisms in neurodegenerative disease (review). Chinese Journal of Neuroscience 2001, 17: 379-384.

Ling X, Zhang LM, Lu SD, Li XJ, Sun FY. Protection of melatonin against injured cerebral neurons is associated with bcl-2 protein over-expression. Acta Pharmacol. Sin. 1999, 20: 409-414. PMID: 10678086.

Li XJ, Gu J, Pan BS, Sun FY. Effect of melatonin on the production of hydroxyl radical and LDH during anoxia in rat cortical slice. Acta Pharmacol. Sin. 1999, 20: 201-205. PMID: 10452092.

Gu J, Li XJ, Sun FY. Melatonin decreases the release of amino acid transmitters in hypoxic rat cortical slice. Sheng Li Xue Bao. 1999, 51: 445-448. PMID: 11498975.

Li XJ, Sun FY. Hydroxyl radical and cerebral ischemia (review). Chinese Pharmacol. Bulletin 1998, 14: 44-48.

Li XJ, Zhang LM, Gu J, Zhang AZ, Sun FY. Melatonin decreases product of hydroxyl radical during cerebral ischemia-reperfusion. Acta Pharmacol. Sin. 1997, 18: 394-396. PMID: 10322924.

Li XJ, Pan BS, Zhang LM, Gu J, Gu YJ, Sun FY. Measurement of hydroxyl radicals in rat brain in vivo. Acta Acad. Med. Shanghai 1997, 24: 299-301.


For Complete list of publication in PubMed:

Dr. Mathew’s Lab Heading link

Royhman D, Yuan JC, Shokuhfar T, Takoudis C, Sukotjo C, Mathew MT. An electrochemical investigation of TMJ implant metal alloys in an artificial joint fluid environment: The influence of pH variation, JCMS-D-13-00375R2, Accepted in Journal of Cranio-Maxillofacial Surgery (Jan 2014) [View ]

Butt A, Patel S, Hamlekhan A, Mathew MT, Royhman D, Sukotjo C, Shokuhfar T, Takoudis C. A Novel Investigation of the Formation of TiO2 Nanotubes on Thermally Formed Oxide of Ti-6Al-4V, Accepted in Journal of Oral Implantology (Dec 2013)[View]

Rossman P, Dube A, Shokufar T, Takoudis C, Sukotjo C, Mathew MT, Tribocorrosion Apparatus for Biomedical Applications: Development and Initial Outcomes, Innovations in Corrosion and Materials Science, 2014, 4, 000-000

Royhman D, Dominguez‐Benetton X, Yuan J, Shokuhfar T, Takoudis C, Mathew MT, Sukotjo C. The Role of Nicotine in the Corrosive Behavior of a Ti‐6Al‐4V Dental Implant, Clinical implant dentistry and related research. [View ]

Patel S, Butt A, Tao Q, Rossero AJ,Royhman D, Mathew MT, Shokuhfar T, Sukotjo C, Takoudis CG. Enhancing Surface Characteristics of Ti-6Al-4V for Bio-implants Using Integrated Anodization and Thermal Oxidation, accepted Journal of Materials Chemistry B. (April 2014)

Hamlekhan A, Butt A, Patel S, Takoudis CG, Cortino S, Gregory J, Mathew MT, William H, Virdi A, Shokuhfar T. Fabrication of Anti-Aging TiO2 Nanotubes on Biomedical Ti Alloys; Accepted in PloS One (Feb 2014) [View ]

Faverani LP, Assunção WG, de Carvalho PS, Yuan JC, Sukotjo C, Mathew MT, Barao VA. of Dextrose and Lipopolysaccharide on the Corrosion Behavior of a Ti-6Al-4V Alloy with a Smooth Surface or Treated with Double-Acid-Etching Effects, PLoS One. (March 2014) [View]

Mathew MT, Kerwell S, Lundberg HJ, Sukotjo C, Mercuri LJ. Tribocorrosion and Oral and maxillofacial Surgical Devices, BJOMS-D-14-00003, Accepted in The British Journal of Oral & Maxillofacial Surgery (Jan 2014) [View ]

Royhman D, Yuan JC, Shokuhfar T, Takoudis C, Sukotjo C, Mathew MT. An electrochemical investigation of TMJ implant metal alloys in an artificial joint fluid environment: The influence of pH variation, JCMS-D-13-00375R2, Accepted in Journal of Cranio-Maxillofacial Surgery (Jan 2014) [View ]

Butt A, Patel S, Hamlekhan A, Mathew MT, Royhman D, Sukotjo C, Shokuhfar T, Takoudis C. A Novel Investigation of the Formation of TiO2 Nanotubes on Thermally Formed Oxide of Ti-6Al-4V, Accepted in Journal of Oral Implantology (Dec 2013) [View ]


For Complete list of publication in Pubmed: